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- ***************************************************************
- * Enterobacterial virulence outer membrane protein signatures *
- ***************************************************************
-
- A number of enterobacterial outer membrane proteins which are involved in
- virulence and seem to promote the invasion of bacteria into eukaryotic cells
- have been shown [1,2] to be structurally related. These proteins are listed
- below.
-
- - Enterobacter cloacae outer membrane protein X (gene ompX).
- - Salmonella typhimurium virulence membrane protein pagC.
- - Yersinia enterocolitica attachment invasion locus protein (gene ail).
- - Bacteriophage lambda outer membrane protein lom. Lom is expressed during
- lysogeny in Escherichia coli.
- - Escherichia coli hypothetical protein ybiG.
-
- These outer membrane proteins have from 150 to 170 amino acid residues and
- their sequences are well conserved. We selected the two most highly conserved
- regions as signature patterns. The first pattern is located in the N-terminal
- section of these proteins; the second is located at the C-terminal extremity.
-
- -Consensus pattern: G-[LIVMFY]-N-[LIVM]-K-Y-R-Y-E
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Consensus pattern: [FYW]-x(2)-G-x-G-Y-[KR]-F>
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Last update: June 1994 / Text revised.
-
- [ 1] van de Klundert J.A.M.
- J. Bacteriol. 173:156-160(1991).
- [ 2] Pulkkinen W.S., Miller S.I.
- J. Bacteriol. 173:86-93(1991).
-